NAKAZAWA HIROMITSU
逆に、経皮吸収する塗り薬や化粧品の観点から考えると、皮膚バリア機能は大きな障壁となります。この場合、角層細胞間脂質の構造を一時的に乱して、皮膚バリア機能を低下させることが要求されます。
私の研究の目的は、この皮膚角層、特に細胞間脂質の構造特性をX線(放射光)や電子線を用いて明らかにすることにより、皮膚機能の改善や、より浸透しやすい薬品(経皮吸収薬)の開発に役立てることにあります。企業での研究経験を活かし、多くの企業と連携を図りながら当研究を展開しています。
興味があれば以下までご連絡下さい。
(e-mail) nakazawa@kwansei.ac.jp
Degree 【 display / non-display 】
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Degree name:博士(理学)
Classified degree field:Nanotechnology/Materials / Thin film/surface and interfacial physical properties
Conferring institution:Kwansei Gakuin University
Acquisition way:Thesis
Date of acquisition:2015.07
Career 【 display / non-display 】
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Affiliation:Setsunan University
Department:理工学部
Title:Lecturer
Date:2020.09 - -
Affiliation:Kobe University
Department:国際教養教育院
Title:Lecturer
Date:2019.04 - -
Affiliation:University of Hyogo
Department:理学部
Title:Lecturer
Date:2018.04 - 2019.03 -
Affiliation:Kwansei Gakuin University
Department:School of Science and Technology Department of Physics
Title:Research Assistant
Date:2005.04 - -
Department:基礎科学研究所
Title:Researcher
Date:2002.04 - 2005.03
Association Memberships 【 display / non-display 】
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Academic society name:日本放射光学会
Academic country located:Japan -
Academic society name:日本香粧品学会
Academic country located:Japan -
Academic society name:コロイドおよび界面化学部会
Academic country located:Japan -
Academic society name:日本生物物理学会
Academic country located:Japan -
Academic society name:日本薬学会
Academic country located:Japan
Research Areas 【 display / non-display 】
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Research field:Natural Science / Biophysics, chemical physics and soft matter physics
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Research field:Life Science / Dermatology
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Research field:Nanotechnology/Materials / Thin film/surface and interfacial physical properties
Research Career 【 display / non-display 】
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Research subject: 皮膚角層の構造解析研究
Periods of research: 2015.04 -
Classification of research form:Collaboration in Japan
Research program:Grant-in-Aid for Scientific Research
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Research subject: 皮膚角層の構造解析研究
Periods of research: 2005.04 -
Classification of research form:Collaboration in Japan
Research program:Cooperative Research
Papers 【 display / non-display 】
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Language: English
Title: Analysis of Correlation between Electron Diffraction Images of Corneocytes and Skin Barrier Properties by Multilayer Perceptron and Convolutional Neural Network.
Journal name: Sensors and Materials vol.36 (6) (p.2557 - 2568)
Date of publication: 2024.06
Author(s): Yoshifumi Takahashi, Yusuke Iida, Hiromitsu NakazawaDOI: https://doi.org/10.18494/SAM5013
Type of publication: Research paper (scientific journal)
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Language: English
Title: Low-flux electron diffraction study on body site dependence of stratum corneum structures in human skin.
Journal name: Biochim. Biophys. Acta vol.1864 (9) (p.183933 - )
Date of publication: 2022.04
Author(s): Hiromitsu Nakazawa,Tomohiro Imai, Ichiro Hatta, Satoru KatoDOI: 10.1016/j.bbamem.2022.183933
Type of publication: Research paper (scientific journal)
Co-author classification: Multiple Authorship
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Language: Japanese
Title: Development of a Bicelle Lotion Containing a High Concentration of Ceramide.
Journal name: J.Soc.Cosmet.Chem.Jpn. vol.33 (5) (p.249 - 254)
Date of publication: 2021.09
Author(s): D. Tsukamoto, H. Nakazawa, et al.DOI: 10.5107/sccj.55.249
Type of publication: Research paper (scientific journal)
Co-author classification: Multiple Authorship
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Language: English
Title: Stratum Corneum Function: A Structural Study with Dynamic Synchrotron X-ray Diffraction Experiments
Journal name: Journal of Oleo Science vol.70 (9) (p.1181 - 1199)
Date of publication: 2021.08
Author(s): Ichiro Hatta, Hiromitsu Nakazawa, Noboru Ohta, Tomonobu Uchino, Kaori YanaseDOI: https://doi.org/10.5650/jos.ess21159
Type of publication: Research paper (scientific journal)
Co-author classification: Multiple Authorship
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Language: English
Title: Raman Study on Lipid Droplets in Hepatic Cells Co-Cultured with Fatty Acids
Journal name: International Journal of Molecular Sciences vol.22 (14) (p.7378 - )
Date of publication: 2021.07
Author(s): Pradjna N. Paramitha, Riki Zakaria, Anisa Maryani, Yukako Kusaka, Bibin B. Andriana, Kosuke Hashimoto, Hiromitsu Nakazawa, Satoru Kato, Hidetoshi SatoDOI: 10.3390/ijms22147378
Type of publication: Research paper (scientific journal)
Co-author classification: Multiple Authorship
Books 【 display / non-display 】
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Language: Japanese
Title: Analyzing the interactions between transdermal substances and the skin stratum corneum.
Publisher: Fragrance J., 504(50-6)
Date of publication: 2022.06
Author(s): Hiromitsu Nakazawa
Type of books: Scholarly book
Authorship:Sole author
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Language: Japanese
Title: Analysis of the behavior of water in the stratum corneum, a factor important for understanding the skin barrier function.
Publisher: Fragrance J., 503(50-5)
Date of publication: 2022.05
Author(s): Hiromitsu Nakazawa
Type of books: Scholarly book
Authorship:Sole author
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Language: Japanese
Title: 化粧品の機能創製・処方・素材開発・解析評価技術と美容理論
Publisher: 技術教育出版社
Date of publication: 2022.02
Author(s): 中沢 寛光 他
Type of books: Scholarly book
Authorship:Contributor
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Language: Japanese
Title: 皮膚の測定・評価法バイブル
Publisher: 技術情報協会
Date of publication: 2013.05
Author(s): 八田一郎、中沢寛光 他
Type of books: Scholarly book
Authorship:Contributor
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Language: Japanese
Title: シンクロトロン放射光物質科学最前線 先端未踏領域を照らし出す英知の光
Publisher: アドスリー
Date of publication: 2010.04
Author(s): 高橋功、加藤知、中沢寛光 他
Type of books: Scholarly book
Authorship:Joint author
MISC 【 display / non-display 】
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Language:Japanese
Title:ヒト皮膚角層の構造と物質透過性
Journal name:オレオサイエンス vol.15 (11) (p.5 - 12)
Date of publication:2015.11
Author(s):加藤 知、中沢 寛光Type of publication:Article, review, commentary, editorial, etc. (scientific journal)
Industrial Property Rights 【 display / non-display 】
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Property type:Patent
Title:口唇荒れの評価方法
Inventor(s)/Creator(s):中沢 寛光 他
Application number:2020-182278(P2020-182278), 2020.10.30
Publication number:2022-72691(P2022-72691A), 2022.05.17
Country:Japan
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Property type:Patent
Title:人工膜を用いた皮膚角層細胞間脂質の機能評価方法
Inventor(s)/Creator(s):中沢 寛光,加藤 知 他
Application number:特願2017-252799, 2017.12.28
Publication number:特開2019-120492, 2019.07.22
Country:Japan
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Property type:Patent
Title:敏感肌の評価方法
Inventor(s)/Creator(s):内田 崇志、加藤 知、中沢 寛光
Application number:特願2016-045327、2016/3/9, 2016.03.09
Publication number:特開2017-161328、2017/9/14, 2017.09.14
Country:Japan
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Property type:Patent
Title:試料保持装置および試料分析方法
Inventor(s)/Creator(s):中沢寛光,加藤知
Application number:特願2012-071442, 2012.03.27
Publication number:特許第5904835号, 2016.03.25
Country:Japan
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Property type:Patent
Title:角層細胞の物性測定方法
Inventor(s)/Creator(s):小栗雅史、中沢寛光 他2名
Application number:2010-239111, 2010.10.25
Country:Japan
Examination request:Yes
Research Projects 【 display / non-display 】
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Research category:基盤研究(C)
Project year:2023.04 - 2026.03
Title:経皮吸収促進の作用メカニズムの解明研究
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Project year:2021.03 - 2023.03
Title:電流場などの外部刺激が薬剤の経皮吸収に与える影響の解析
Awarding organization:Ministry of Economy, Trade and Industry
System name:NEDO 官民による若手研究者発掘支援事業費助成
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Research category:Grant-in-Aid for Scientific Research(C)
Title:角層水分量に着目した電場による経皮吸収促進メカニズムの解明研究
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Research category:Grant-in-Aid for Scientific Research(C)
Project year:2019.04 - 2022.03
Title:角層水分量に着目した電場による経皮吸収促進メカニズムの解明研究
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Research category:Grant-in-Aid for Scientific Research(C)
Project year:2015.04 - 2019.03
Title:皮膚角層の構造と溶液吸収特性の関係解明に関する研究-電場及び超音波の影響の解明-
Preferred joint research theme 【 display / non-display 】
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Preferred joint research theme: Analysis of permeation of the human stratum corneum under various external environments.
Joint research form:No Setting
Possible form for cooperating Industry-Academia Collaboration:No Setting
Teaching Experience (Off-campus) 【 display / non-display 】
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Subject:基礎物理学実験Ⅱ
Institution name:Kwansei Gakuin University -
Subject:基礎物理学実験Ⅰ
Institution name:Kwansei Gakuin University -
Subject:物理学実験(光学、電気回路学)
Institution name: -
Subject:物理学実験(力学、熱力学)
Institution name: -
Subject:物理学実験(熱力学)
Institution name: