Personnel Information

写真b

OKIYONEDA Tsukasa

Organization
School of Biological and Environmental Sciences Department of Biomedical Sciences
Research Fields, Keywords
分子細胞生物学, 生化学, 薬理学
Teaching and Research Fields
膜タンパク質、タンパク質品質管理、難治性疾患、自然免疫
Syllabus information URL
https://syllabus.kwansei.ac.jp/uniasv2/UnSSOLoginControlFree?REQ_ACTION_DO=/AGA030PLS01Action.do?REQ_FUNCTION_JUMP_START_FLG=1&SLB_LINK_DISP_FLG=305&TCH_NO=130013&REQ_PRFR_FUNC_ID=AGA030
SDGs Related Goals
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Graduating School 【 display / non-display 】

  • Graduating School:Kumamoto University
    Faculty:Faculty of Pharmaceutical Science

    Kind of school:University
    Date of graduation:1998.03
    Completion status:Graduated
    Country location code:Japan

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Graduate School 【 display / non-display 】

  • Graduate school:Kumamoto University
    Department:Graduate School, Division of Pharmaceutical Sciences

    Course completed:Doctor's Course
    Date of completion:2003.03
    Completion status:Completed
    Country:Japan

  • Graduate school:Kumamoto University
    Department:Graduate School, Division of Pharmaceutical Sciences

    Course completed:Master's Course
    Date of completion:2000.03
    Completion status:Completed
    Country:Japan

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Studying abroad experiences 【 display / non-display 】

  • Name of institution: McGill University
    Name of job or career: リサーチアソシエイト
    Date: 2008.06 - 2013.03

  • Name of institution: Hospital for Sick Children Research Institute
    Name of job or career: 博士研究員
    Date: 2006.04 - 2008.05

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Degree 【 display / non-display 】

  • Degree name:薬学博士
    Classified degree field:Life Science / Pharmaceutical hygiene and biochemistry
    Conferring institution:Kumamoto University
    Acquisition way:Coursework
    Date of acquisition:2003.03

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Career 【 display / non-display 】

  • Affiliation:Kwansei Gakuin University
    Department:School of Science and Technology Department of Biomedical Chemistry
    Title:Professor
    Date:2019.04 -

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Association Memberships 【 display / non-display 】

  • Academic society name:日本分子生物学会
    Academic country located:Japan

  • Academic society name:日本薬学会
    Academic country located:Japan

  • Academic society name:日本生化学会
    Academic country located:Japan

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Research Areas 【 display / non-display 】

  • Research field:Life Science / Pharmacology

  • Research field:Life Science / Functional biochemistry

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Qualification acquired 【 display / non-display 】

  • Qualification title:Pharmacist

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Papers 【 display / non-display 】

  • Language: English
    Title: Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase
    Journal name: Developmental Cell  vol.44  (6)  (p.694 - 708)
    Date of publication: 2018.03
    Author(s): Okiyoneda T, Veit G, Sakai R, Aki M, Fujihara T, Higashi M, Susuki-Miyata S, Miyata M, Fukuda N, Yoshida A, Xu H, Apaja PM, Lukacs GL

    DOI: 10.1016/j.devcel.2018.02.001
    Type of publication: Research paper (scientific journal)
    Co-author classification: Multiple Authorship

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  • Language: English
    Title: Mechanism-based corrector combination restores ΔF508-CFTR folding and function.
    Journal name: Nat Chem Biol. [Epub ahead of print]
    Date of publication: 2013.05
    Author(s): Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL.

    DOI: 10.1038/nchembio.1253.
    Type of publication: Research paper (scientific journal)
    Co-author classification: Multiple Authorship

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  • Language: English
    Title: Peripheral protein quality control removes unfolded CFTR from the plasma membrane.
    Journal name: Science. (Article). Comment in Science 329(5993):766-7 (2010), Highlighted in Nature vol 466, p162, 2010, Recommended by Faculty of 1000  vol.329  (5993)  (p.805 - 810)
    Date of publication: 2010.08
    Author(s): Okiyoneda T, Barrière H, Bagdány M, Rabeh WM, Du K, Höhfeld J, Young JC, Lukacs GL.

    DOI: 10.1126/science.1191542.
    Type of publication: Research paper (scientific journal)
    Co-author classification: Multiple Authorship

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  • Title: UBE3C Facilitates the ER-Associated and Peripheral Degradation of Misfolded CFTR
    Journal name: CELLS  vol.12  (23)
    Date of publication: 2023.12
    Author(s): Kamada Yuka, Tateishi Hazuki, Nakayamada Uta, Hinata Daichi, Iwasaki Ayuka, Zhu Jingxin, Fukuda Ryosuke, Okiyoneda Tsukasa

    DOI: 10.3390/cells12232741

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  • Title: Identification of a-Tocopherol succinate as an RFFL-substrate interaction inhibitor inducing peripheral CFTR stabilization and apoptosis
    Journal name: BIOCHEMICAL PHARMACOLOGY  vol.215
    Date of publication: 2023.09
    Author(s): Taniguchi Sachiho, Ono Yuji, Doi Yukako, Taniguchi Shogo, Matsuura Yuta, Iwasaki Ayuka, Hirata Noriaki, Fukuda Ryosuke, Inoue Keitaro, Yamaguchi Miho, Tashiro Anju, Egami Daichi, Aoki Shunsuke, Kondoh Yasumitsu, Honda Kaori, Osada Hiroyuki, Kumeta Hiroyuki, Saio Tomohide, Okiyoneda Tsukasa

    DOI: 10.1016/j.bcp.2023.115730

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MISC 【 display / non-display 】

  • Language：Japanese
    Title:嚢胞性線維症原因遺伝子産物CFTRの品質管理機構と機能制御
    Publisher:公益社団法人日本生化学会
    Journal name:生化学  vol.92  (2)  (p.179 - 188)
    Date of publication:2020.04
    Author(s):福田 亮介，沖米田 司

    DOI:doi:10.14952/SEIKAGAKU.2020.920179
    Type of publication：Article, review, commentary, editorial, etc. (bulletin of university, research institution)

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  • Language：Japanese
    Title:嚢胞性線維症のユビキチン創薬
    Journal name:ファルマシア
    Date of publication:2020.01
    Author(s):沖米田司

    Type of publication：Article, review, commentary, editorial, etc. (scientific journal)

  • Language：Japanese
    Title:嚢胞性線維症における上皮細胞の水の輸送障害を理解する
    Journal name:消化器病学サイエンス  vol.3  (2)  (p.82 - 86)
    Date of publication:2019
    Author(s):福田亮介, 沖米田司

    Type of publication：Article, review, commentary, editorial, etc. (scientific journal)

  • Language：Japanese
    Title:異常な形質膜タンパク質を除去する新しい品質管理機構
    Journal name:生化学  vol.86  (1)  (p.54 - 58)
    Date of publication:2014.02
    Author(s):沖米田司

    Type of publication：Article, review, commentary, editorial, etc. (scientific journal)

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Industrial Property Rights 【 display / non-display 】

  • Property type:Patent
    Title:嚢胞性線維症予防又は治療剤
    Inventor(s)/Creator(s):沖米田司

    Application number:PCT/JP2018/009524, 2018.03.12
    Publication number:WO2018/168777, 2018.09.20
    Country:Japan

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Research Projects 【 display / non-display 】

  • Research category:Grant-in-Aid for Scientific Research(B)
    Project year：2022.04 - 2025.03
    Title:哺乳類 ERAD における逆輸送機構の包括的理解

  • Research category:Grant-in-Aid for Scientific Research on Innovative Areas (Research in a Proposed Research Area)
    Project year：2021.04 - 2023.03
    Title:CFTR ユビキチン化制御剤の創出と CF 創薬への応用

  • Research category:Grant-in-Aid for Scientific Research(B)
    Project year：2019.04 - 2022.03
    Title:PMQCにおけるユビキチン化制御分子の機能解明と治療的応用

  • Research category:Grant-in-Aid for Scientific Research(B)
    Project year：2019.04 - 2022.03
    Title:PMQCにおけるユビキチン化制御分子の機能解明と治療的応用

  • Research category:Grant-in-Aid for Scientific Research on Innovative Areas (Research in a Proposed Research Area)
    Project year：2019.04 - 2021.03
    Title:RFFL による形質膜タンパク質品質管理作動機構の解明と CF 創薬への応用

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Presentations 【 display / non-display 】

  • Language:Japanese
    Conference name:第 96 回日本生化学会大会　シンポジウム "分泌経路の新しいタンパク質輸送・修飾システム”
    International/Domestic presentation:Domestic presentation
    Presentation date：2023.10.31
    Title:翻訳後修飾による膜タンパク質CFTRの品質管理
    Presentation type:Oral presentation (invited, special)

  • Language:Japanese
    Conference name:第95回日本生化学会大会 シンポジウム「ユビキチンワールドを制御する脱ユビキチン化酵素の疾患、創薬における重要性」
    International/Domestic presentation:Domestic presentation
    Presentation date：2022.11.10
    Title:DUBを標的とした嚢胞性線維症の治療戦略

  • Language:Japanese
    Conference name:第 92 回日本生化学大会シンポジウム タンパク質の運命を制御する動態と疾病のフロンティア
    International/Domestic presentation:Domestic presentation
    Presentation date：2019.09.19
    Title:ミスフォールディングが誘発する嚢胞性線維症の理解
    Presentation type:Oral presentation (invited, special)

  • Language:Japanese
    Conference name:日本ケミカルバイオロジー学会第14回年会 ミニシンポジウム
    International/Domestic presentation:Domestic presentation
    Presentation date：2019.06.11
    Title:嚢胞性線維症治療薬開発を目指した RFFL ユビキチンリガーゼ PPI 阻害剤の探索
    Presentation type:Oral presentation (invited, special)

  • Language:Japanese
    Conference name:第46回日本分子生物学会年会シンポジウム2PS-17 遅延制御による脳機能障害および神経変性疾患の理解
    International/Domestic presentation:Domestic presentation
    Holding date：2023.12
    Title:sgRNAゲノムワイドスクリーニングによる新規CFTR品質管理分子の同定
    Presentation type:Oral presentation (general)

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Committee Memberships 【 display / non-display 】

  • Organization name:Frontiers in Pharmacology
    Committee name:Topic Editor
    Date：2023 - 2024

  • Organization name:Frontiers in Pharmacology (Pharmacology of Ion Channel and Channelopathies)
    Committee name:Associate Editor

  • Organization name:Frontiers in Cell and Developmental Biology- Cellular Biochemistry
    Committee name:Review Editor

  • Organization name:Frontiers in Molecular Biosciences - Cellular Biochemistry
    Committee name:Review Editor

  • Organization name:International Journal of Molecular Sciences
    Committee name:Topic Editor
    Date：2022

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Social Contribution 【 display / non-display 】

  • Title:平成29年度JSPSサマー・プログラム　留学生受入
    Date：2017.06 - 2017.08

  • Title:熊本大学薬学部　大学院セミナー
    Date：2014.12

  • Title:関西学院創立125周年 世界市民フォーラムin大阪 「いま、科学技術を学ぶということ～ボーダーレス化する知の世界～」
    Date：2014.07

  • Title:関西学院大学オープンラボ「免疫の力を使って、病原体を見つけよう！」ひらめき☆ときめきサイエンス事業
    Date：2014.07

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