Personnel Information

写真b

NAKAZAWA HIROMITSU

Organization
School of Science
Date of Birth
1976
Laboratory Address
Gakuen Uegahara 1, Sanda, Hyougo
Research Fields, Keywords
皮膚角層, 経皮吸収, 化粧品
Profile
　皮膚の重要な役割の一つとして、アレルゲンなどの物質が体内へ侵入することを防ぐ、いわゆる皮膚バリア機能が挙げられます。このバリア機能は、皮膚の最外層に位置する厚さわずか10μm程度の角層と呼ばれる領域が担っており、正常な皮膚バリア機能を保つためには、角層中に存在する細胞間脂質（セラミドなど）が正常な構造を形成していなければなりません。近年、アトピー性皮膚炎などの皮疹部において、この細胞間脂質の構造に乱れが生じていることがわかってきました。
　逆に、経皮吸収する塗り薬や化粧品の観点から考えると、皮膚バリア機能は大きな障壁となります。この場合、角層細胞間脂質の構造を一時的に乱して、皮膚バリア機能を低下させることが要求されます。
　私の研究の目的は、この皮膚角層、特に細胞間脂質の構造特性をＸ線（放射光）や電子線を用いて明らかにすることにより、皮膚機能の改善や、より浸透しやすい薬品（経皮吸収薬）の開発に役立てることにあります。企業での研究経験を活かし、多くの企業と連携を図りながら当研究を展開しています。
興味があれば以下までご連絡下さい。
(e-mail) nakazawa@kwansei.ac.jp
Mail Address
nakazawa@kwansei.ac.jp
Laboratory Phone number
+81-79-565-8093
Laboratory Fax number
+81-79-565-8093
Syllabus information URL
https://syllabus.kwansei.ac.jp/uniasv2/UnSSOLoginControlFree?REQ_ACTION_DO=/AGA030PLS01Action.do?REQ_FUNCTION_JUMP_START_FLG=1&SLB_LINK_DISP_FLG=105&TCH_NO=050035&REQ_PRFR_FUNC_ID=AGA030
SDGs Related Goals
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Degree 【 display / non-display 】

  • Degree name:博士（理学）
    Classified degree field:Nanotechnology/Materials / Thin film/surface and interfacial physical properties
    Conferring institution:Kwansei Gakuin University
    Acquisition way:Thesis
    Date of acquisition:2015.07

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Career 【 display / non-display 】

  • Affiliation:Setsunan University
    Department:理工学部
    Title:Lecturer
    Date:2020.09 -

  • Affiliation:Kobe University
    Department:国際教養教育院
    Title:Lecturer
    Date:2019.04 -

  • Affiliation:University of Hyogo
    Department:理学部
    Title:Lecturer
    Date:2018.04 - 2019.03

  • Affiliation:Kwansei Gakuin University
    Department:School of Science and Technology Department of Physics
    Title:Research Assistant
    Date:2005.04 -

  • Department:基礎科学研究所
    Title:Researcher
    Date:2002.04 - 2005.03

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Association Memberships 【 display / non-display 】

  • Academic society name:日本放射光学会
    Academic country located:Japan

  • Academic society name:日本香粧品学会
    Academic country located:Japan

  • Academic society name:コロイドおよび界面化学部会
    Academic country located:Japan

  • Academic society name:日本生物物理学会
    Academic country located:Japan

  • Academic society name:日本薬学会
    Academic country located:Japan

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Research Areas 【 display / non-display 】

  • Research field:Natural Science / Biophysics, chemical physics and soft matter physics

  • Research field:Life Science / Dermatology

  • Research field:Nanotechnology/Materials / Thin film/surface and interfacial physical properties

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Research Career 【 display / non-display 】

  • Research subject: 皮膚角層の構造解析研究

    Periods of research: 2015.04 -
    Classification of research form:Collaboration in Japan
    Research program:Grant-in-Aid for Scientific Research

  • Research subject: 皮膚角層の構造解析研究

    Periods of research: 2005.04 -
    Classification of research form:Collaboration in Japan
    Research program:Cooperative Research

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Papers 【 display / non-display 】

  • Language: English
    Title: Low-flux electron diffraction study on body site dependence of stratum corneum structures in human skin.
    Journal name: Biochim. Biophys. Acta  vol.1864  (9)  (p.183933 - )
    Date of publication: 2022.04
    Author(s): Hiromitsu Nakazawa,Tomohiro Imai, Ichiro Hatta, Satoru Kato

    DOI: 10.1016/j.bbamem.2022.183933
    Type of publication: Research paper (scientific journal)
    Co-author classification: Multiple Authorship

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  • Language: Japanese
    Title: Development of a Bicelle Lotion Containing a High Concentration of Ceramide.
    Journal name: J.Soc.Cosmet.Chem.Jpn.  vol.33  (5)  (p.249 - 254)
    Date of publication: 2021.09
    Author(s): D. Tsukamoto, H. Nakazawa, et al.

    DOI: 10.5107/sccj.55.249
    Type of publication: Research paper (scientific journal)
    Co-author classification: Multiple Authorship

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  • Language: English
    Title: Stratum Corneum Function: A Structural Study with Dynamic Synchrotron X-ray Diffraction Experiments
    Journal name: Journal of Oleo Science  vol.70  (9)  (p.1181 - 1199)
    Date of publication: 2021.08
    Author(s): Ichiro Hatta, Hiromitsu Nakazawa, Noboru Ohta, Tomonobu Uchino, Kaori Yanase

    DOI: https://doi.org/10.5650/jos.ess21159
    Type of publication: Research paper (scientific journal)
    Co-author classification: Multiple Authorship

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  • Language: English
    Title: Raman Study on Lipid Droplets in Hepatic Cells Co-Cultured with Fatty Acids
    Journal name: International Journal of Molecular Sciences  vol.22  (14)  (p.7378 - )
    Date of publication: 2021.07
    Author(s): Pradjna N. Paramitha, Riki Zakaria, Anisa Maryani, Yukako Kusaka, Bibin B. Andriana, Kosuke Hashimoto, Hiromitsu Nakazawa, Satoru Kato, Hidetoshi Sato

    DOI: 10.3390/ijms22147378
    Type of publication: Research paper (scientific journal)
    Co-author classification: Multiple Authorship

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  • Language: English
    Title: Simultaneous Measurements of Structure and Water Permeability in an Isolated Human Skin Stratum Corneum Sheet
    Journal name: Polymers  vol.11  (5)  (p.829 - 839)
    Date of publication: 2019.05
    Author(s): Hiromitsu Nakazawa, et al.

    DOI: 10.3390/polym11050829
    Type of publication: Research paper (scientific journal)
    Co-author classification: Multiple Authorship
    Field of experts:Life Science / Dermatology, Natural Science / Biophysics, chemical physics and soft matter physics

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Books 【 display / non-display 】

  • Language: Japanese
    Title: Analyzing the interactions between transdermal substances and the skin stratum corneum.
    Publisher: Fragrance J., 504(50-6)
    Date of publication: 2022.06
    Author(s): Hiromitsu Nakazawa

    Type of books: Scholarly book
    Authorship: Sole author

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  • Language: Japanese
    Title: Analysis of the behavior of water in the stratum corneum, a factor important for understanding the skin barrier function.
    Publisher: Fragrance J., 503(50-5)
    Date of publication: 2022.05
    Author(s): Hiromitsu Nakazawa

    Type of books: Scholarly book
    Authorship: Sole author

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  • Language: Japanese
    Title: 化粧品の機能創製・処方・素材開発・解析評価技術と美容理論
    Publisher: 技術教育出版社
    Date of publication: 2022.02
    Author(s): 中沢 寛光　他

    Type of books: Scholarly book
    Authorship: Contributor

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  • Language: Japanese
    Title: 皮膚の測定・評価法バイブル
    Publisher: 技術情報協会
    Date of publication: 2013.05
    Author(s): 八田一郎、中沢寛光　他

    Type of books: Scholarly book
    Authorship: Contributor

  • Language: Japanese
    Title: シンクロトロン放射光物質科学最前線　先端未踏領域を照らし出す英知の光
    Publisher: アドスリー
    Date of publication: 2010.04
    Author(s): 高橋功、加藤知、中沢寛光　他

    Type of books: Scholarly book
    Authorship: Joint author

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MISC 【 display / non-display 】

  • Language:Japanese
    Title:ヒト皮膚角層の構造と物質透過性
    Journal name:オレオサイエンス  vol.15  (11)  (p.5 - 12)
    Date of publication:2015.11
    Author(s):加藤 知、中沢 寛光

    Type of publication:Article, review, commentary, editorial, etc. (scientific journal)

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Industrial Property Rights 【 display / non-display 】

  • Property type:Patent
    Title:口唇荒れの評価方法
    Inventor(s)/Creator(s):中沢　寛光　他

    Application number:2020-182278(P2020-182278), 2020.10.30
    Publication number:2022-72691(P2022-72691A), 2022.05.17
    Country:Japan

  • Property type:Patent
    Title:人工膜を用いた皮膚角層細胞間脂質の機能評価方法
    Inventor(s)/Creator(s):中沢　寛光，加藤　知　他

    Application number:特願2017-252799, 2017.12.28
    Publication number:特開2019-120492, 2019.07.22
    Country:Japan

  • Property type:Patent
    Title:敏感肌の評価方法
    Inventor(s)/Creator(s):内田 崇志、加藤 知、中沢 寛光

    Application number:特願2016-045327、2016/3/9, 2016.03.09
    Publication number:特開2017-161328、2017/9/14, 2017.09.14
    Country:Japan

  • Property type:Patent
    Title:試料保持装置および試料分析方法
    Inventor(s)/Creator(s):中沢寛光，加藤知

    Application number:特願2012-071442, 2012.03.27
    Publication number:特許第5904835号, 2016.03.25
    Country:Japan

  • Property type:Patent
    Title:角層細胞の物性測定方法
    Inventor(s)/Creator(s):小栗雅史、中沢寛光　他2名

    Application number:2010-239111, 2010.10.25
    Country:Japan
    Examination request:Yes

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Research Projects 【 display / non-display 】

  • Research category:基盤研究(C)
    Project year:2023.04 - 2026.03
    Title:経皮吸収促進の作用メカニズムの解明研究

  • Research category:
    Project year:2021.03 - 2023.03
    Title:電流場などの外部刺激が薬剤の経皮吸収に与える影響の解析
    Awarding organization：Ministry of Economy, Trade and Industry
    System name：NEDO　官民による若手研究者発掘支援事業費助成

  • Research category:Grant-in-Aid for Scientific Research(C)
    Project year:2019.04 -
    Title:角層水分量に着目した電場による経皮吸収促進メカニズムの解明研究

  • Research category:Grant-in-Aid for Scientific Research(C)
    Project year:2019.04 - 2022.03
    Title:角層水分量に着目した電場による経皮吸収促進メカニズムの解明研究

  • Research category:Grant-in-Aid for Scientific Research(C)
    Project year:2015.04 - 2019.03
    Title:皮膚角層の構造と溶液吸収特性の関係解明に関する研究-電場及び超音波の影響の解明-

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Preferred joint research theme 【 display / non-display 】

  • Preferred joint research theme: Analysis of permeation of the human stratum corneum under various external environments.
    Joint research form:No Setting
    Possible form for cooperating Industry-Academia Collaboration:No Setting

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Teaching Experience (Off-campus) 【 display / non-display 】

  • Subject：物理学実験（光学、電気回路学）
    Institution name：

  • Subject：物理学実験（力学、熱力学）
    Institution name：

  • Subject：物理学実験（熱力学）
    Institution name：

  • Subject：機能分子薬学特論Ⅱ（オムニバス）
    Institution name：

  • Subject：理学特別プログラム
    Institution name：Kwansei Gakuin University

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