Personnel Information

写真b

AONO YUICHI

Organization
School of Biological and Environmental Sciences
Research Fields, Keywords
分子細胞生物学, ケミカルバイオロジー
Profile
私たちは身近に存在する天然物質を利用することで様々な恩恵を受けています。例えば、漢方薬は膨大な経験知によって選び抜かれた「疾患に対して効果を示す天然物質」の利用したものであり、その他の治療薬も天然物質をヒントに創製されたものが約半数を占めています。これらの物質は、私たちの体を形作る細胞内外の分子ネットワークに作用することで薬効・副作用をもたらします。ゆえに、その作用機序を理解することは生命現象の理解にも繋がります。我々は薬効・副作用を持つ天然化合物から皮膚・軟骨形成に関連する疾患を中心に、その発症メカニズムの究明および治療薬創製のヒントとなり得る標的分子の発見を目指し研究を行っていきます。
Syllabus information URL
https://syllabus.kwansei.ac.jp/uniasv2/UnSSOLoginControlFree?REQ_ACTION_DO=/AGA030PLS01Action.do?REQ_FUNCTION_JUMP_START_FLG=1&SLB_LINK_DISP_FLG=638&TCH_NO=196068&REQ_PRFR_FUNC_ID=AGA030
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Graduating School 【 display / non-display 】

  • Graduating School:Kwansei Gakuin University
    Faculty:Faculty of Science and Engineering
    Course / Major:生命科学科

    Kind of school:University
    Date of graduation:2010.03
    Completion status:Graduated
    Country location code:Japan

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Graduate School 【 display / non-display 】

  • Graduate school:Kwansei Gakuin University
    Department:Graduate School, Division of Science and Engineering
    Course:生命科学専攻

    Course completed:Master's Course
    Date of completion:2012.03
    Completion status:Completed
    Country:Japan

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Degree 【 display / non-display 】

  • Degree name:博士（医学）
    Classified degree field:Life Science / Medical management and medical sociology
    Conferring institution:Kyoto Prefectural University of Medicine
    Acquisition way:Coursework
    Date of acquisition:2019.01

  • Degree name:修士（理学）
    Classified degree field:Life Science / Developmental biology
    Conferring institution:Kwansei Gakuin University
    Acquisition way:Coursework
    Date of acquisition:2012.03

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Association Memberships 【 display / non-display 】

  • Academic society name:日本がん分子標的治療学会
    Academic country located:Japan

  • Academic society name:日本衛生学会
    Academic country located:Japan

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Research Areas 【 display / non-display 】

  • Research field:Life Science / Medical biochemistry

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Papers 【 display / non-display 】

  • Language: English
    Title: Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2.
    Journal name: Biochemical and Biophysical Research Communications  vol.505  (4)  (p.1203 - 1210)
    Date of publication: 2019.01
    Author(s): Aono Y, Horinaka M, Iizumi Y, Watanabe M, Taniguchi T, Yasuda S, Sakai T

    DOI: 10.1016/j.bbrc.2018.10.050
    Type of publication: Doctoral thesis
    Co-author classification: Multiple Authorship

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  • Title: Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells
    Journal name: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  vol.628  (p.110 - 115)
    Date of publication: 2022.11
    Author(s): Imai Ayaka, Horinaka Mano, Aono Yuichi, Iizumi Yosuke, Takakura Hideki, Ono Hisako, Yasuda Shusuke, Taniguchi Keiko, Nishimoto Emi, Ishikawa Hideki, Mutoh Michihiro, Sakai Toshiyuki

    DOI: 10.1016/j.bbrc.2022.08.082

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  • Title: Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol
    Journal name: COMMUNICATIONS BIOLOGY  vol.5  (1)
    Date of publication: 2022.06
    Author(s): Iizumi Yosuke, Sowa Yoshihiro, Goi Wakana, Aono Yuichi, Watanabe Motoki, Kurumida Yoichi, Kameda Tomoshi, Akaji Kenichi, Kitagawa Masatoshi, Sakai Toshiyuki

    DOI: 10.1038/s42003-022-03522-6

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  • Language: English
    Title: Sodium salicylate and 5-aminosalicylic acid synergistically inhibit the growth of human colon cancer cells and mouse intestinal polyp-derived cells
    Journal name: Journal of Clinical Biochemistry and Nutrition  vol.70  (2)  (p.93 - 102)
    Date of publication: 2022
    Author(s): Takakura Hideki, Horinaka Mano, Imai Ayaka, Aono Yuichi, Nakao Toshimasa, Miyamoto Shingo, Iizumi Yosuke, Watanabe Motoki, Narita Takumi, Ishikawa Hideki, Mutoh Michihiro, Sakai Toshiyuki

    DOI: 10.3164/jcbn.21-74

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  • Language: English
    Title: Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2.
    Journal name: Biochemical and Biophysical Research Communications  vol.505  (4)  (p.1203 - 1210)
    Date of publication: 2018.11
    Author(s): Aono Y, Horinaka M, Iizumi Y, Watanabe M, Taniguchi T, Yasuda S, Sakai T

    DOI: 10.1016/j.bbrc.2018.10.050
    Type of publication: Research paper (scientific journal)
    Co-author classification: Multiple Authorship

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Research Projects 【 display / non-display 】

  • Research category:若手研究
    Project year:2023.04 - 2025.03
    Title:疾病予防を目的としたヒノキチオールが示す抗酸化効果の作用機序の解明

  • Research category:Grant-in-Aid for Early-Career Scientists
    Project year:2020.04 - 2023.03
    Title:皮膚がん予防への応用に向けたヒノキチオールの新規標的分子の発見と作用機序の解明

  • Research category:Grant-in-Aid for JSPS Fellows
    Project year:2015.04 - 2017.03
    Title:がん予防におけるアスピリンの新規標的タンパク質の探索と作用機序の解析

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Presentations 【 display / non-display 】

  • Language: Japanese
    Conference name: 第89回日本衛生学会学術総会
    International/Domestic presentation: Domestic presentation
    Holding date: 2019.02

    Title: スリンダク代謝体の大腸腺腫形成抑制作用における新規標的分子の探索と作用機序の解析
    Presentation type: Oral presentation (general)

  • Language: Japanese
    Conference name: 第18回分子予防環境医学研究会大会
    International/Domestic presentation: Domestic presentation
    Holding date: 2019.01

    Title: 新規スリンダクスルホン結合タンパク質VDACによる細胞周期制御のメカニズムの解析
    Presentation type: Oral presentation (general)

  • Language: English
    Conference name: 第63回日本細胞生物学会大会
    International/Domestic presentation: Domestic presentation
    Holding date: 2011.06

    Title: 哺乳類の脊椎軟骨形成が追跡可能な新規培養系の構築
    Presentation type: Poster presentation

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