Field of expertise (Grants-in-aid for Scientific Research classification) 【 display / non-display

  • Field of expertise (Grants-in-aid for Scientific Research classification):Cell biology

 

Papers 【 display / non-display

  • Written language: English
    Title of paper: Hedgehog Signal and Genetic Disorders.
    Publication title: Frontiers in genetics  vol.10  (p.1103)
    Date of issue: 2019
    Name of author(s): Noriaki Sasai, Michinori Toriyama, Toru Kondo

    DOI: 10.3389/fgene.2019.01103
    Type of publication: Research paper (scientific journal)
    Co-author classification: Joint Work

  • Written language: Other
    Title of paper: Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance.
    Publication title: eLife  vol.7
    Date of issue: 2018.08
    Name of author(s): Baba K, Yoshida W, Toriyama M, Shimada T, Manning CF, Saito M, Kohno K, Trimmer JS, Watanabe R, Inagaki N

    DOI: 10.7554/eLife.34593
    Type of publication: Research paper (scientific journal)
    Co-author classification: Joint Work

  • Written language: Other
    Title of paper: Grip and slip of L1-CAM on adhesive substrates direct growth cone haptotaxis
    Publication title: Proceedings of the National Academy of Sciences of the United States of America  vol.115  (11)  (p.2764 - 2769)
    Date of issue: 2018.03
    Name of author(s): Abe K, Katsuno H, Toriyama M, Baba K, Mori T, Hakoshima T, Kanemura Y, Watanabe R, Inagaki N

    DOI: 10.1073/pnas.1711667115
    Type of publication: Research paper (scientific journal)
    Co-author classification: Joint Work

  • Written language: English
    Title of paper: Folate-dependent methylation of septins governs ciliogenesis during neural tube closure
    Publication title: FASEB JOURNAL  vol.31  (8)  (p.3622 - 3635)
    Date of issue: 2017.08
    Name of author(s): Manami Toriyama, Michinori Toriyama, John B. Wallingford, Richard H. Finnell

    DOI: 10.1096/fj.201700092R
    Type of publication: Research paper (scientific journal)
    Co-author classification: Joint Work

  • Written language: English
    Title of paper: The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery
    Publication title: NATURE GENETICS  vol.48  (6)  (p.648 - +)
    Date of issue: 2016.06
    Name of author(s): Michinori Toriyama, Chanjae Lee, S. Paige Taylor, Ivan Duran, Daniel H. Cohn, Ange-Line Bruel, Jacqueline M. Tabler, Kevin Drew, Marcus R. Kelly, Sukyoung Kim, Tae Joo Park, Daniela A. Braun, Ghislaine Pierquin, Armand Biver, Kerstin Wagner, Anne Malfroot, Inusha Panigrahi, Brunella Franco, Hadeel Adel Al-Lami, Yvonne Yeung, Yeon Ja Choi, Yannis Duffourd, Laurence Faivre, Jean-Baptiste Riviere, Jiang Chen, Karen J. Liu, Edward M. Marcotte, Friedhelm Hildebrandt, Christel Thauvin-Robinet, Deborah Krakow, Peter K. Jackson, John B. Wallingford

    DOI: 10.1038/ng.3558
    Type of publication: Research paper (scientific journal)
    Co-author classification: Joint Work

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Grant-in-Aid for Scientific Research 【 display / non-display

  • Research item:Grant-in-Aid for Scientific Research(C)
    Research activities period:2021.04 - 2024.03

Other external funds procured 【 display / non-display

  • Fund:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)
    Research activities period:2017.04 - 2020.03
    Research Topic:Study of neural circuit formation regulated by primary cilia

    Funding organization name:Japan Society for the Promotion of Science

  • Fund:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Research activities period:2011.04 - 2014.03
    Research Topic:Slow axonal transport driven by directional actin turnover

    Description of research:Although actin and associated proteins are essential for axonal extension, how they are transported along axons remains unclear. Here we show that actin filaments (F-actins) and associated proteins migrate toward the axonal growth cone by means of directional actin polymerization/depolymerization, called treadmilling. F-actins migrating along axonal shafts underwent treadmilling, with their polymerizing ends oriented toward the growth cone. F-actins were anchored to the plasma membrane through the cell adhesion molecule L1-CAM and the linker protein shootin1. Migration of F-actins depended on their polymerization and substrate anchorage, and directional counter-forces associated with F-actin migration were detected on the substrate. Actin-associated proteins co-migrated with F-actins by interacting with the filaments. Our findings reveal a new mode of intracellular transport, which supplies actin and associated proteins to the axonal leading edge, thereby promoting its protrusion.

    Funding organization name:Japan Society for the Promotion of Science

  • Fund:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Research activities period:2011 - 2012
    Research Topic:Mechanism of oriented-axon outgrowth in developmentalbrain

    Description of research:Here we show that shootin1 is located at a critical interface, transducing a chemical signal into traction forces for axon outgrowth. We found that a netrin-1 positively regulates Pak1-mediated shootin1 phosphorylation. This phosphorylation enhanced the interaction between shootin1 and F-actin retrograde flow, thereby promoting F-actin-substrate coupling, force generation, and axon outgrowth. These results suggest that dynamic actin-substrate coupling can transduce chemical signals into mechanical forces to control cellular motility and provide a molecular-level description of how this transduction may occur.

    Funding organization name:Japan Society for the Promotion of Science

  • Fund:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (Start-up)
    Research activities period:2008 - 2009
    Research Topic:Analysis of the neuronal polarity formation mechanism induced by extracellular signals

    Description of research:Netrin-1 stimulation elevated shootin1 phosphorylation via PAK1. And phosphorylated shootin1 promoted neuronal polarity formation. These results suggest that extracellular molecule Netrin-1 regulates neuronal polarization by promoting shootin1 phosphorylation and activating its activity

    Funding organization name:Japan Society for the Promotion of Science