Personnel Information

写真b

MIYAKE Takahito

Organization
School of Biological and Environmental Sciences Associate Professor
Research Fields, Keywords
Circadian clock, Molecular Biology, 温度生物学, Biochemistry, Neuroscience
Teaching and Research Fields
我々が⽣きゆく上でおきるさまざまな⽣理/⽣命現象は、体内の各所でおきる⽣化学反応の連鎖と
調和に基づき⽣み出されます。私たちの研究室では、この⽣化学反応が「いつ」「どこで」「どの
ように」制御されるのかに着⽬し、研究を進めています。特に、⽣化学反応の基幹変動因⼦である
温度、⽣命の時間の根源である⽣物時計を中⼼的に取り扱い、脳神経をはじめとした各臓器、およ
びその臓器の中の細胞の機能制御機構について明らかにします。病とは、⽣化学連鎖反応の不調和
・破綻に起因します。そのため私は、これらの研究を通じて、⼈々の健康の増進に少しでも貢献し
たいと考えています。また⼀連の研究活動を通して、学⽣のみなさまには、論理的な思考⼒を育ん
でいただくと同時に、社会で活躍するために必要なプレゼンテーション能⼒・⽂章作成能⼒を会得
していただければと考えています。
Syllabus information URL
https://syllabus.kwansei.ac.jp/uniasv2/UnSSOLoginControlFree?REQ_ACTION_DO=/AGA030PLS01Action.do?REQ_FUNCTION_JUMP_START_FLG=1&SLB_LINK_DISP_FLG=689&TCH_NO=250008&REQ_PRFR_FUNC_ID=AGA030
SDGs Related Goals
External link
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Graduating School 【 display / non-display 】

  • Graduating School:Kyoto University
    Faculty:Faculty of Pharmaceutical Scieonces
    Course / Major:Division of Pharmaceutical Sciences

    Kind of school:University
    Date of graduation:2012.03
    Completion status:Graduated

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Graduate School 【 display / non-display 】

  • Graduate school:Kyoto University
    Department:大学院薬学研究科

    Course completed:Doctor's Course
    Date of completion:2017.03
    Completion status:Completed
    Country:Japan

  • Graduate school:Kyoto University
    Department:大学院薬学研究科

    Course completed:Master's Course
    Date of completion:2014.03
    Completion status:Completed
    Country:Japan

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Studying abroad experiences 【 display / non-display 】

  • Name of institution: University of California, San Francisco
    Name of job or career: Postdoctoral Fellow
    Date: 2017.05 - 2018.10

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Degree 【 display / non-display 】

  • Degree name:博士（薬科学）
    Classified degree field:Life Science / Pharmacology
    Conferring institution:Kyoto University
    Acquisition way:Coursework
    Date of acquisition:2017.03

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Career 【 display / non-display 】

  • Affiliation:Kwansei Gakuin University
    Department:School of Biological and Environmental Sciences Department of Biomedical Sciences
    Title:Associate Professor
    Date:2025.04 -

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  • Affiliation:Graduate School of Pharmaceutical Sciences, Kyoto University
    Department:Department of Systems Biology
    Title:Assistant Professor
    Date:2018.10 - 2025.03

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  • Affiliation:University of California, San Francisco
    Department:Department of Physiology
    Title:Postdoctoral scholar
    Date:2017.05 - 2018.11

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  • Affiliation:Graduate School of Pharmaceutical Sciences, Kyoto University
    Department:Department of Molecular Pharmacology
    Title:Researcher
    Date:2017.04

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  • Affiliation:Kyoto University
    Title:Assistant Professor

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Association Memberships 【 display / non-display 】

  • Academic society name:THE PHARMACEUTICAL SOCIETY OF JAPAN
    Academic country located:Japan

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  • Academic society name:THE JAPAN NEUROSCIENCE SOCIETY
    Academic country located:Japan

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  • Academic society name:日本時間生物学会
    Academic country located:Japan

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  • Academic society name:日本分子生物学会
    Academic country located:Japan

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  • Academic society name:日本内分泌学会
    Academic country located:Japan

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Research Areas 【 display / non-display 】

  • Research field:Life Science / Cell biology

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  • Research field:Life Science / Neuroscience-general

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  • Research field:Life Science / Molecular biology

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  • Research field:Life Science / Metabolism and endocrinology

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  • Research field:Life Science / Pharmaceutical hygiene and biochemistry

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Qualification acquired 【 display / non-display 】

  • Qualification title:Pharmacist

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Papers 【 display / non-display 】

  • Language: English
    Title: Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior.
    Journal name: Cell reports methods  vol.4  (10)  (p.100881)
    Date of publication: 2024.10
    Author(s): Takahito Miyake, Kaho Tanaka, Yutsuki Inoue, Yuji Nagai, Reo Nishimura, Takehito Seta, Shumpei Nakagawa, Ken-Ichi Inoue, Emi Hasegawa, Takafumi Minamimoto, Masao Doi

    DOI: 10.1016/j.crmeth.2024.100881
    Type of publication: Research paper (scientific journal)

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  • Language: English
    Title: Circadian Clock and Body Temperature
    Journal name: Advances in Experimental Medicine and Biology  vol.1461  (p.177 - 188)
    Date of publication: 2024.09
    Author(s): Takahito Miyake, Yuichi Inoue, Yota Maekawa, Masao Doi

    DOI: 10.1007/978-981-97-4584-5_12
    Type of publication: Part of collection (book)

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  • Title: Omeprazole Induces CYP3A4 mRNA Expression but Not CYP3A4 Protein Expression in HepaRG Cells
    Journal name: Biological and Pharmaceutical Bulletin  vol.47  (6)  (p.1218 - 1223)
    Date of publication: 2024.06
    Author(s): Yuto Fujita, Takahito Miyake, Xinyan Shao, Yuto Aoki, Emi Hasegawa, Masao Doi

    DOI: 10.1248/bpb.b24-00161
    Type of publication: Research paper (scientific journal)

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  • Language: English
    Title: Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm.
    Journal name: Cell reports  vol.42  (3)  (p.112157)
    Date of publication: 2023.02
    Author(s): Takahito Miyake, Yuichi Inoue, Xinyan Shao, Takehito Seta, Yuto Aoki, Khanh Tien Nguyen Pham, Yuichi Shichino, Junko Sasaki, Takehiko Sasaki, Masahito Ikawa, Yoshiaki Yamaguchi, Hitoshi Okamura, Shintaro Iwasaki, Masao Doi

    DOI: 10.1016/j.celrep.2023.112157
    Type of publication: Research paper (scientific journal)

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  • Language: English
    Title: Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS
    Journal name: NATURE COMMUNICATIONS  vol.7
    Date of publication: 2016.09
    Author(s): Takahito Miyake, Saki Nakamura, Meng Zhao, Kanako So, Keisuke Inoue, Tomohiro Numata, Nobuaki Takahashi, Hisashi Shirakawa, Yasuo Mori, Takayuki Nakagawa, Shuji Kaneko

    DOI: 10.1038/ncomms12840
    Type of publication: Research paper (scientific journal)

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MISC 【 display / non-display 】

  • Title:TRPV4開口はミクログリアの活性化状態を抗炎症型へ分極させる
    Journal name:日本薬理学雑誌  vol.155  (Supplement)
    Date of publication:2020
    Author(s):桑田沙織, 富澤恵里, 三宅崇仁, 永安一樹, 白川久志, 金子周司

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  • Title:オリゴデンドロサイト前駆細胞におけるTRPV4開口は増殖を促進する
    Journal name:日本薬理学会近畿部会プログラム・要旨集  vol.133rd
    Date of publication:2018
    Author(s):大橋佳奈, 出屋敷綾音, 三宅崇仁, 永安一樹, 柴崎貢志, 白川久志, 金子周司

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  • Title:ノイロトロピンは持続性K<sub>v</sub>電流増加を介してDRGニューロンの活動を抑制する
    Journal name:Pain Research  vol.33  (2)
    Date of publication:2018
    Author(s):河合洋幸, 浅岡希美, 三宅崇仁, 永安一樹, 中川貴之, 白川久志, 金子周司

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  • Title:ミクログリアにおいてTRPV4の開口はLPS誘発IL10産生を促進する
    Journal name:日本薬理学会近畿部会プログラム・要旨集  vol.132nd
    Date of publication:2017
    Author(s):富澤恵里, 三宅崇仁, 永安一樹, 白川久志, 金子周司

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  • Title:オリゴデンドロサイト前駆細胞の増殖および分化におけるTRPV4の生理的役割
    Journal name:日本薬理学会近畿部会プログラム・要旨集  vol.130th
    Date of publication:2016
    Author(s):出屋敷綾音, 三宅崇仁, 永安一樹, 白川久志, 中川貴之, 金子周司

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Awards 【 display / non-display 】

  • Prize: 奨励賞
    Date awarded:2024.11
    Awarding organization：日本薬学会

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  • Prize: 奨励賞
    Date awarded:2024.08
    Awarding organization：日本時間生物学会

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  • Prize: 長井記念若手薬学研究者賞
    Date awarded:2022.03
    Awarding organization：日本薬学会

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  • Prize: 優秀ポスター賞
    Date awarded:2024.02
    Awarding organization：先端モデル動物プラットフォーム
    Award-winner (group):三宅崇仁

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  • Prize: ナノシンポジウム優秀発表賞
    Date awarded:2017.03
    Awarding organization：日本薬理学会
    Award-winner (group):三宅 崇仁

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Research Projects 【 display / non-display 】

  • Research category:挑戦的研究（萌芽）
    Project year：2025.04 - 2027.03
    Title:温度生物学新ツールが拓く熱中症と猛暑の連関

  • Research category:基盤研究(B)
    Project year：2024.04 - 2028.03
    Title:uORFー非翻訳領域の翻訳ーが支配する生命機能の解明

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Presentations 【 display / non-display 】

  • Language:Japanese
    Conference name:日本薬学会第145年会
    Presentation date：2025.03.28
    Title:温度と活性酸素種を介した生命の環境適応機構の解明
    Presentation type:Symposium, workshop panel (nominated)

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  • Language:Japanese
    Conference name:第4回日本神経化学会 若手KYOUEN
    Presentation date：2025.02.15
    Title:ポスト転写制御がもたらす生命機能の解明に向けて
    Presentation type:Symposium, workshop panel (nominated)

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  • Language:Japanese
    Conference name:第31回 日本時間生物学会学術大会
    Presentation date：2024.11.18
    Title:概日体温リズムによる転写によらない生物時計調律機構の解明
    Presentation type:Symposium, workshop panel (nominated)

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  • Language:Japanese
    Conference name:第97回日本生化学会大会
    Presentation date：2024.11.07
    Title:Post-transcriptional制御による体内時計時刻調律機構
    Presentation type:Symposium, workshop panel (public)

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  • Language:English
    Conference name:日本薬学会第144年会
    Presentation date：2024.03.29
    Title:The minimal upstream open reading frame of Per2 has a role in enhancing the integrity of the physiological circadian response
    Presentation type:Poster presentation

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