Personnel Information

写真b

YAMAGUCHI Hiroshi

Organization
School of Science Department of Chemistry Professor
Research Fields, Keywords
構造生物学, 蛋白質結晶学
Teaching and Research Fields
生体内の化学反応をつかさどり、全ての生命現象に関与している重要な物質にタンパク質がある。タンパク質がどのようにして働いているのかを理解することは、生物学的にも化学的にも重要である。そこで、研究対象のタンパク質の立体構造をX線結晶解析法を用いて決定し、他の物理化学的手法や生化学的手法を援用し、構造という観点から機能を理解するという構造生物学を推進している。
Syllabus information URL
https://syllabus.kwansei.ac.jp/uniasv2/UnSSOLoginControlFree?REQ_ACTION_DO=/AGA030PLS01Action.do?REQ_FUNCTION_JUMP_START_FLG=1&SLB_LINK_DISP_FLG=734&TCH_NO=970150&REQ_PRFR_FUNC_ID=AGA030
SDGs Related Goals
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Graduating School 【 display / non-display 】

  • Graduating School:Osaka University
    Faculty:Faculty of Science
    Course / Major:Department of macromolecular science

    Kind of school:University
    Date of graduation:1986.03
    Completion status:Graduated
    Country location code:Japan

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Graduate School 【 display / non-display 】

  • Graduate school:Osaka University
    Department:Graduate School, Division of Natural Science
    Course:高分子学専攻

    Course completed:Doctor's Course
    Date of completion:1991.03
    Completion status:Completed
    Country:Japan

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Degree 【 display / non-display 】

  • Degree name:理学博士
    Classified degree field:Nanotechnology/Materials / Polymer chemistry
    Conferring institution:Osaka University
    Acquisition way:Coursework
    Date of acquisition:1991.03

  • Degree name:理学修士
    Classified degree field:Nanotechnology/Materials / Polymer chemistry
    Conferring institution:Osaka University
    Acquisition way:Coursework
    Date of acquisition:1988.03

  • Degree name:理学士
    Classified degree field:Nanotechnology/Materials / Polymer chemistry
    Conferring institution:Osaka University
    Acquisition way:Coursework
    Date of acquisition:1986.03

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Career 【 display / non-display 】

  • Affiliation:Kwansei Gakuin University
    Department:School of Science and Technology Department of Chemistry
    Title:Professor
    Date:2008.04 -

  • Affiliation:Kwansei Gakuin University
    Department:School of Science and Technology
    Title:Associate Professor
    Date:2007.04 - 2008.03

  • Affiliation:Kwansei Gakuin University
    Department:School of Science and Technology
    Title:Associate Professor (as old post name)
    Date:2002.04 - 2007.03

  • Affiliation:Kwansei Gakuin University
    Department:Abolition organization
    Title:Assistant Professor
    Date:1997.04 - 2002.03

  • Affiliation:Osaka University
    Department:蛋白質研究所
    Title:Research Assistant
    Date:1992.10 - 1997.03

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Association Memberships 【 display / non-display 】

  • Academic society name:日本化学会
    Academic country located:Japan

  • Academic society name:日本結晶学会
    Academic country located:Japan

  • Academic society name:日本生物物理学会
    Academic country located:Japan

  • Academic society name:日本農芸化学会
    Academic country located:Japan

  • Academic society name:日本蛋白質科学会
    Academic country located:Japan

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Research Areas 【 display / non-display 】

  • Research field:Life Science / Structural biochemistry

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Papers 【 display / non-display 】

  • Title: Comparison of Evolutionary Relationships between <i>Branchiostoma floridae</i>, <i>Ciona intestinalis</i>, and <i>Homo sapiens</i> Globins Provide Evidence of Gene Co-Option and Convergent Evolution
    Journal name: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  vol.24  (21)
    Date of publication: 2023.11
    Author(s): Yano Nanako, Minamoto Toshifumi, Yamaguchi Hirosi, Goto Toshiyuki, Nishikata Takahito

    DOI: 10.3390/ijms242116009

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  • Title: Functional Interplay between P5 and PDI/ERp72 to Drive Protein Folding
    Journal name: BIOLOGY-BASEL  vol.10  (11)
    Date of publication: 2021.11
    Author(s): Matsusaki Motonori, Okada Rina, Tanikawa Yuya, Kanemura Shingo, Ito Dai, Lin Yuxi, Watabe Mai, Yamaguchi Hiroshi, Saio Tomohide, Lee Young-Ho, Inaba Kenji, Okumura Masaki

    DOI: 10.3390/biology10111112

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  • Title: Ca2+ Regulates ERp57-Calnexin Complex Formation
    Journal name: MOLECULES  vol.26  (10)
    Date of publication: 2021.05
    Author(s): Tanikawa Yuya, Kanemura Shingo, Ito Dai, Lin Yuxi, Matsusaki Motonori, Kuroki Kimiko, Yamaguchi Hiroshi, Maenaka Katsumi, Lee Young-Ho, Inaba Kenji, Okumura Masaki

    DOI: 10.3390/molecules26102853

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  • Language: English
    Title: Inhibitory effects of local anesthetics on the proteasome and their biological actions
    Journal name: #IScientific Reports#IR.  vol.7  (p.5079 - )
    Date of publication: 2017
    Author(s): U. Bahrudin, M. Unno, K. Nishio, A. Kita, P. Li, M. Kato, M. Inoue, S. Tsujitani, T. Murakami, R. Sugiyama, Y. Saeki, Y. Obara, K. Tanaka, H. Yamaguchi, I. Sakane, Y. Kawata, T. Itoh, H. Ninomiya, I. Hisatome & Y. Morimot

    DOI: doi:10.1038/s41598-017-04652-2
    Type of publication: Research paper (scientific journal)
    Co-author classification: Multiple Authorship

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  • Language: English
    Title: Trapping Mechanism of Bioactive Conformation by Intra-molecular Chaperone
    Journal name: #IPeptide Science 2014#IR.  vol.51  (p.95 - 96)
    Date of publication: 2015
    Author(s): Y. Yokyama, M. Okumura, S. Shimamoto, H. Yamaguchi, and Y.Hidaka

    Type of publication: Research paper (scientific journal)
    Co-author classification: Multiple Authorship

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Books 【 display / non-display 】

  • Language: Japanese
    Title: タンパク質結晶の最前線
    Publisher: シーエムシー出版
    Date of publication: 2013
    Author(s): 山口宏

    Type of books: Scholarly book
    Area of responsibility: 小分子添加剤としてアミノ酸類を用いたタンパク質の結晶化
    Authorship：Contributor

  • Language: English
    Title: Time-resolved analysis of catalytic reaction of copper amine oxidase from Arthrobacter globiformis.
    Publisher: The XXII International Congress and General Assembly of the International Union of Crystallography. Madrid, Spain. 22-30, August. 2011.
    Date of publication: 2011.08
    Author(s): H. Yamaguchi, M. Kataoka, H. Oya, A. Tominaga, M. Ohtsu, T. Okajima and K. Tanizawa

    Type of books: Scholarly book
    Authorship：Joint author

  • Language: Japanese
    Title: タンパク質溶液のデザイン法，Bio Industry,25, 38-45
    Publisher: シーエムシー出版
    Date of publication: 2008.04
    Author(s): 白木賢太郎，伊藤廉，山口宏

    Type of books: Scholarly book
    Authorship：Joint author

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Industrial Property Rights 【 display / non-display 】

  • Property type:Patent
    Title:リフォールディング剤および蛋白質のリフォールディング方法
    Inventor(s)/Creator(s):山口宏，山田英俊，伊藤廉，葛西祐介

    Application number:特願2010-535805, 2009.10.27
    Patent/Registration number:特許第5637857号, 2014.10.31
    Country:Japan

  • Property type:Patent
    Title:リフォールディング剤および蛋白質のリフォールディング方法
    Inventor(s)/Creator(s):山口宏，山田英俊，伊藤廉，葛西祐介

    Application number:PCT/JP2009/068438, 2009.10.27
    Country:

  • Property type:Patent
    Title:蛋白質結晶化剤および蛋白質結晶化剤を用いた蛋白質結晶化方法
    Inventor(s)/Creator(s):山口宏，伊藤廉

    Application number:PCT/JP2007/068192, 2007.09.19
    Country:

  • Property type:Patent
    Title:蛋白質結晶化剤および蛋白質結晶化剤を用いた蛋白質結晶化方法
    Inventor(s)/Creator(s):山口宏，伊藤廉

    Application number:特願2009-500055, 2007.09.19
    Patent/Registration number:特許第5484041号, 2014.02.28
    Country:Japan

  • Property type:Patent
    Title:PROTEIN CRYSTALLIZING AGENT AND METHOD OF CRYSTALLIZING PROTEIN THEREWITH
    Inventor(s)/Creator(s):Hiroshi Yamaguchi，Len Ito

    Application number:12/449,657, 2007.09.19
    Patent/Registration number:US8,367,412, 2013.02.05
    Country:United States

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Research Projects 【 display / non-display 】

  • Project year：2011.10 - 2012.09
    Title:脱化石原料のための分子改変による植物由来有機合成原料の創出（戦略的創造研究推進事業　先端的低炭素化技術開発　ALCA）
    Awarding organization：独立行政法人科学技術振興機構

  • Project year：2011.08 - 2012.03
    Title:蛋白質構造解析のための新規結晶化剤を用いた効率的な蛋白質結晶化法の開発（研究成果展開事業　研究成果最適展開支援プログラムＡ－ＳＴＥＰ探索タイプ）
    Awarding organization：独立行政法人科学技術振興機構

  • Project year：2002.07 - 2007.03
    Title:神経幹細胞分化制御タンパク質群の構造解析（タンパク３０００プロジェクト）
    Awarding organization：文部科学省

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Presentations 【 display / non-display 】

  • Language:Japanese
    Conference name:第49回ペプチド討論会　
    International/Domestic presentation:Domestic presentation
    Holding date：2012.11
    Title:内分泌撹乱物質によるプロテインジスルフィドイソメラーゼの構造変化
    Presentation type:Oral presentation (general)

  • Language:Japanese
    Conference name:第49回ペプチド討論会
    International/Domestic presentation:Domestic presentation
    Holding date：2012.11
    Title:アミロイド前駆体タンパク質の可溶性細胞外領域SAPPαのpH依存的構造変化
    Presentation type:Oral presentation (general)

  • Language:Japanese
    Conference name:第５０回生物物理学会
    International/Domestic presentation:Domestic presentation
    Holding date：2012.09
    Title:20S プロテアソームの機能阻害とＸ線結晶構造解析
    Presentation type:Oral presentation (general)

  • Language:Japanese
    Conference name:第１２回蛋白質科学会
    International/Domestic presentation:Domestic presentation
    Holding date：2012.06
    Title:プロ領域によるジスルフィド結合含有ペプチドの立体構造形成制御機構
    Presentation type:Oral presentation (general)

  • Language:Japanese
    Conference name:第１２回蛋白質科学会
    International/Domestic presentation:Domestic presentation
    Holding date：2012.06
    Title:アミロイド前駆体タンパク質の可溶性細胞外領域sAPPαのpH 依存的構造変化
    Presentation type:Oral presentation (general)

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Committee Memberships 【 display / non-display 】

  • Organization name:日本結晶学会
    Committee name:評議員
    Date：2017.04 - 2019.03

  • Organization name:学術振興会産学協同回折構造生物第169委員会
    Committee name:幹事

  • Organization name:日本結晶学会
    Committee name:男女共同参画委員
    Date：2012.04 - 2016.03

  • Organization name:日本結晶学会
    Committee name:行事委員
    Date：2008.04 - 2012.03

  • Organization name:日本結晶学会
    Committee name:評議員
    Date：2008.04 - 2011.03

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Social Contribution 【 display / non-display 】

  • Title:SPring-8利用者懇談会 編集幹事
    Date：2009.12 - 2011.03

  • Title:日本学術振興会産学協力研究委員会「回折構造生物第169委員会」学界委員
    Date：2001.01 - 2014.12

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