Personnel Information

写真b

HIRAI Yohei

Organization
School of Biological and Environmental Sciences Department of Biomedical Sciences Professor
Research Fields, Keywords
Cell Biology, Developmental Biology, Regenerative Medicine, 再生医療, 発生生物学, 細胞生物学
Teaching and Research Fields
発生・再生・組織分化制御学
Syllabus information URL
https://syllabus.kwansei.ac.jp/uniasv2/UnSSOLoginControlFree?REQ_ACTION_DO=/AGA030PLS01Action.do?REQ_FUNCTION_JUMP_START_FLG=1&SLB_LINK_DISP_FLG=175&TCH_NO=090018&REQ_PRFR_FUNC_ID=AGA030
SDGs Related Goals
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Graduating School 【 display / non-display 】

  • Graduating School:Kyoto University
    Faculty:Faculty of Engineering

    Kind of school:University
    Date of graduation:1984.04
    Completion status:Graduated
    Country location code:Japan

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Graduate School 【 display / non-display 】

  • Graduate school:Kyoto University
    Department:Graduate School, Division of Engineering

    Course completed:Master's Course
    Date of completion:1986.03
    Completion status:Completed
    Country:Japan

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Studying abroad experiences 【 display / non-display 】

  • Name of institution: カリフォルニア大学　ローレンスバークレー研究所　米国
    Name of job or career: ポストドクトラルフェロー
    Date: 1995.09 - 1998.11

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Degree 【 display / non-display 】

  • Degree name:博士（理学）
    Classified degree field:Life Science / Cell biology
    Conferring institution:Kyoto University
    Acquisition way:Thesis
    Date of acquisition:1995.03

  • Degree name:工学修士
    Classified degree field:Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering
    Conferring institution:Kyoto University
    Acquisition way:Coursework
    Date of acquisition:1986.03

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Career 【 display / non-display 】

  • Affiliation:Kwansei Gakuin University
    Title:Professor
    Date:2009.04 -

  • Affiliation:Kyoto University
    Title:Associate Professor
    Date:2004.10 - 2009.03

  • Title:Research Fellow
    Date:1998.11 - 2004.09

  • Title:Postdoctoral Fellow
    Date:1995.10 - 1998.11

  • Title:Researcher
    Date:1987.02 - 1994.03

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Association Memberships 【 display / non-display 】

  • Academic society name:日本細胞生物学会
    Academic country located:Japan

  • Academic society name:日本再生医療学会
    Academic country located:Japan

  • Academic society name:日本発生生物学会
    Academic country located:Japan

  • Academic society name:日本研究培養皮膚学会
    Academic country located:Japan

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Research Areas 【 display / non-display 】

  • Research field:Life Science / Medical biochemistry

  • Research field:Life Science / Developmental biology

  • Research field:Life Science / Cell biology

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Teacher organization examination execution 【 display / non-display 】

  • School name: Kwansei Gakuin University
    Career status: Professor
    Date of authorization: 2009.04

  • School name: Kyoto University
    Career status: Associate Professor (as old post name)
    Date of authorization: 2004.10

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Research Career 【 display / non-display 】

  • Research subject: 組織の分化制御

    Periods of research: 2012.04 -
    Classification of research form:Individual
    Research program:Grant-in-Aid for Scientific Research

  • Research subject: ペプチドの応用研究

    Periods of research: 2010.04 - 2012.03
    Classification of research form:Collaboration in Japan
    Research program:Research by State Subsidies Other Than National Organization

  • Research subject: 皮膚疾患治療に関する研究

    Periods of research: 2010.04 - 2012.03
    Classification of research form:Individual
    Research program:The Other Research Programs

  • Research subject: 皮膚疾患に関する研究

    Periods of research: 2009.04 -
    Classification of research form:Collaboration in Japan
    Research program:Cooperative Research

  • Research subject: ES/iPS細胞の分化制御

    Periods of research: 2004.10 -
    Classification of research form:Individual
    Research program:The Other Research Programs

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Papers 【 display / non-display 】

  • Language: English
    Title: PRSS3/mesotrypsin as a putative regulator of the biophysical characteristics of epidermal keratinocytes in superficial layers
    Journal name: Scientific Reports  vol.14  (1)
    Date of publication: 2024.05
    Author(s): Moeko Kida, Junya Abe, Haruna Hori, Yohei Hirai

    DOI: 10.1038/s41598-024-63271-w
    Type of publication: Research paper (scientific journal)
    Field of experts:Life Science / Dermatology, Life Science / Cell biology

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  • Language: English
    Title: The decline in cellular iron is crucial for differentiation in keratinocytes.
    Journal name: Metallomics  vol.16
    Date of publication: 2024.04
    Author(s): Junya Abe, Yuichi Aono, Yohei Hirai

    DOI: 10.1093/mtomcs/mfae014.
    Type of publication: Research paper (scientific journal)
    Field of experts:Life Science / Cell biology, Life Science / Dermatology

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  • Title: CAMSAP3, a microtubule orientation regulator, plays a vital role in manifesting differentiation-dependent characteristics in keratinocytes
    Journal name: EXPERIMENTAL CELL RESEARCH  vol.435  (1)
    Date of publication: 2024.02
    Author(s): Kobori Mako, Abe Junya, Saito Reika, Hirai Yohei

    DOI: 10.1016/j.yexcr.2024.113927

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  • Title: A crucial stem cell plasticity regulation pathway: identification of key elements using the NCCIT human embryonic carcinoma cell line
    Journal name: JOURNAL OF BIOCHEMISTRY  vol.174  (6)  (p.501 - 510)
    Date of publication: 2023.11
    Author(s): Nozaki Sae, Hirai Yohei

    DOI: 10.1093/jb/mvad063

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  • Title: Syntaxin4, P-cadherin, and CCAAT enhancer binding protein 13 as signaling elements in the novel differentiation pathway for cultured embryonic stem cells
    Journal name: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  vol.672  (p.27 - 35)
    Date of publication: 2023.09
    Author(s): Matsuguchi Shuji, Hirai Yohei

    DOI: 10.1016/j.bbrc.2023.06.039

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Books 【 display / non-display 】

  • Language: Japanese
    Title: 　表皮形成におけるEGF受容体とエピモルフィン　
    Publisher: 生体の科学
    Date of publication: 2013
    Author(s): 萩原奈津美、葛野菜々子、平井洋平

    Type of books: Other
    Authorship：Sole author

  • Language: Japanese
    Title: 上皮分化異常を伴う疾患に対する高効率で低副作用の治療・予防薬　
    Publisher: 化学工業　63：264-269　　　　　　
    Date of publication: 2012.04
    Author(s): 葛野菜々子、平井洋平

    Type of books: Scholarly book
    Authorship：Joint author

  • Language: Japanese
    Title: エピモルフィンの膜トポロジーと生理機能　化学と生物　１１月号　
    Publisher: 学会出版センター
    Date of publication: 2009.11
    Author(s): 奥川洋司、平井洋平

    Type of books: Scholarly book
    Authorship：Joint author

  • Language: Japanese
    Title: 地球環境と人類の未来を考える生命科学
    Publisher: アドズリー
    Date of publication: 2009
    Author(s): 平井洋平

    Type of books: Scholarly book
    Authorship：Contributor

  • Language: Japanese
    Title: 再生医療のための細胞生物学：器官形成を制御するエピモルフィン
    Publisher: コロナ社
    Date of publication: 2007.03
    Author(s): 平井洋平

    Type of books: Scholarly book
    Authorship：Contributor

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MISC 【 display / non-display 】

  • Language：Japanese
    Title:毛包上皮幹細胞システムと毛髪の再生　再生医療のいま -基礎研究から臨床への展開に向けて
    Journal name:治療別冊  vol.89  (p.394 - 399)
    Date of publication:2007.02
    Author(s):山本祥也、平井洋平

    Type of publication：Article, review, commentary, editorial, etc. (scientific journal)

  • Language：Japanese
    Title:形態形成誘導蛋白質エピモルフィンの応用―毛包形成を誘導するペプチドの化学合成
    Journal name:化学と工業  vol.56  (p.137 - 139)
    Date of publication:2003.02
    Author(s):岡由美子、平井洋平

    Type of publication：Article, review, commentary, editorial, etc. (scientific journal)

  • Language：Japanese
    Title:エピモルフィンによる上皮形態の形成制御
    Journal name:呼吸  vol.20  (p.833 - 836)
    Date of publication:2001.08
    Author(s):平井洋平

    Type of publication：Article, review, commentary, editorial, etc. (scientific journal)

  • Language：Japanese
    Title:臓器再構築とエピモルフィン
    Journal name:細胞工学  vol.13  (p.798-802 - )
    Date of publication:1994.09
    Author(s):平井洋平

    Type of publication：Article, review, commentary, editorial, etc. (scientific journal)

  • Language：Japanese
    Title:上皮―間葉相互作用におけるエピモルフィン
    Journal name:実験医学  vol.12  (p.47 - 52)
    Date of publication:1994.01
    Author(s):平井洋平

    Type of publication：Article, review, commentary, editorial, etc. (scientific journal)

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Industrial Property Rights 【 display / non-display 】

  • Property type:Patent
    Title:環状ペプチド化合物またはその薬理的に許容される塩、その製造方法、及びその用途
    Inventor(s)/Creator(s):平井洋平，葛野奈々子，他

    Application number:PCT/JP2012/062513, 2012.05.16
    Country:

  • Property type:Patent
    Title:環状ペプチド化合物またはその薬理的に許容される塩、その製造方法、及びその用途
    Inventor(s)/Creator(s):平井洋平，葛野奈々子，他

    Application number:特願2013-515179, 2012.05.16
    Patent/Registration number:特許第5946447号, 2016.06.10
    Country:Japan

  • Property type:Patent
    Title:環状ペプチド化合物またはその薬理的に許容される塩およびその製造方法
    Inventor(s)/Creator(s):平井洋平，奥川洋司

    Application number:PCT/JP2011/065521, 2011.07.06
    Country:

  • Property type:Patent
    Title:CYCLIC PEPTIDE COMPOUND OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF　AND METHOD FOR PRODUCING SAME
    Inventor(s)/Creator(s):Yohei Hirai，Yoji Okugawa

    Application number:201180043462.6, 2011.07.06
    Patent/Registration number:ZL201180043462.6, 2015.07.15
    Country:China

  • Property type:Patent
    Title:CYCLIC PEPTIDE COMPOUND OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF　AND METHOD FOR PRODUCING SAME
    Inventor(s)/Creator(s):Yohei Hirai，Yoji Okugawa

    Application number:11803647.4, 2011.07.06
    Country:

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Research Projects 【 display / non-display 】

  • Project year：2016.04 - 2018.03
    Title:次世代の薬効評価モデルに関売る研究
    Awarding organization：公益財団法人　小林国際財団研究助成
    System name：小林国際財団研究助成

  • Project year：2016.04 - 2017.04
    Title:皮膚老化に抗うペプチド混合物の開発
    Awarding organization：Private Foundations
    System name：一般財団法人ホーユー科学財団　研究助成

  • Research category:Grant-in-Aid for Scientific Research(C)
    Project year：2012.04 - 2015.03
    Title:移植用の高機能細胞凝集体の調製

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  • Project year：2012.04 - 2012.07
    Title:新規環状ペプチド群の外用剤としての応用可能性検討（研究成果展開事業　研究成果最適展開支援プログラムＡ－ＳＴＥＰ探索タイプ）
    Awarding organization：独立行政法人科学技術振興機構

  • Project year：2011.12 - 2012.03
    Title:新規環状ペプチド群の外用剤としての応用可能性検討（研究成果展開事業　研究成果最適展開支援プログラムＡ－ＳＴＥＰ探索タイプ）
    Awarding organization：独立行政法人科学技術振興機構

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Presentations 【 display / non-display 】

  • Language:Japanese
    Conference name: The 67th Annual Meeting of the Japan Society for Cell Biology
    International/Domestic presentation:Domestic presentation
    Holding date：2015.06 - 2015.07
    Title:Impacts of extracellular syntaxin4 on the mammary epithelial cells
    Presentation type:Poster presentation

  • Language:Japanese
    Conference name:The 67th Annual Meeting of the Japan Society for Cell Biology
    International/Domestic presentation:Domestic presentation
    Holding date：2015.06 - 2015.07
    Title:Extracellular extruded syntaxin4 is potent cornification regulator of epidermal keratinocytes
    Presentation type:Poster presentation

  • Language:Japanese
    Conference name:The 67th Annual Meeting of the Japan Society for Cell Biology
    International/Domestic presentation:Domestic presentation
    Holding date：2015.06 - 2015.07
    Title:The t-SNARE Syntaxins exert morphological and differentiation-inducing functions upon their extracellular localization
    Presentation type:Poster presentation

  • Language:Japanese
    Conference name:The 37th Annual Meeting of the Molecular Biology Society of Japan
    International/Domestic presentation:Domestic presentation
    Holding date：2014.11
    Title:細胞外で機能発揮するsyntaxinsの三胚葉分化への影響
    Presentation type:Poster presentation

  • Language:Japanese
    Conference name:The 37th Annual Meeting of the Molecular Biology Society of Japan
    International/Domestic presentation:Domestic presentation
    Holding date：2014.11
    Title:The peptide antagonist ST4n1 of extracellular syntaxin4 prevent abnormal cornification in the skin
    Presentation type:Poster presentation

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